Composition of matter suited to the treatment of nasal allergy and associated conditions



UNITED STATES PATENT OFFICE COMPOSITION OF MATTER SUITED TO TREATMENT OF NASAL ALLERGY AND ASSOCIATED CONDITIONS Edward Everett Edmondson, Canon City, Colo.

No Drawing. Application November 8, 1940, Serial No. 364,934

1 Claim. (01. 167-58) My composition of matter consists of a combi- Other important objects and advantages of my nation of metalic salts of known antiseptic, invention are its action in: stimulant and astringent properties, such as 1. Reducing the intumescence of the nasal cupric sulphate, zinc sulphate and silver nitrate, structures, the named sulphates being so compounded with 5 2. Disinfection of the surfaces of the nasal tisany suitable solvent by heat treatment that they sues,

become miscible with water in all proportions, 3. Stimulation of a discharge of nasal scoreand also can be easily mixed with other diluents tion which may be laden with allergens and other such as starch for use in insufllation and petro undesirable elements,

latum to form an ointment. ll) 4. The development of an increasing tolerance I prefer to dissolve separately the cupric sulfor, and greater immunity against, allergens phate and the zinc sulphate in any suitable solwhich produce nasal symptoms.

vent as glycerol a propenyltrihydroxide whose This is accomplished by so compounding the chemical formula is CH2OHCHOHCH2OH, or ingredients of this. invention that the astringent ethylene glycol whose chemical formula is action is increased over that of any one or two CHzOI-ICHzOI-I converting each such mixture of the chemicals used in this product, without into a clear solution by heat treatment, and then increasing the irritant properties beyond reasoncombine these with an aqueous solution of silver able toleration in the structures involved in nasal nitrate in such proportions that the first or allergy.

weakest solution shall contain substantially 3 20 I have found that the average person can tolgrain of each of said salts to the fluid ounce of erate in comparative comfort to the anatomic water. zone involved in nasal allergy, applications of a Many drugs have been used in efforts to relieve solution of cupric sulphate, zinc sulphate or silnasal allergy and associated conditions by intraver nitrate, containing about a e grain of either nasal application, among which are some of the of said salts to the ounce of water.

acids, such as gallic, tannic and trichloracetic; I have found that frequent repetition of applisalts of aluminum, copper, silver, tin, zinc, usucations of the said strength of this solution soon ally applied singly and by electric modality to increases the tolerance of said anatomic zone till produce iontophoresis; alcohol by injection into a stronger dosage can be applied without special the nasal sensory nerves; and allergens in the o0 discomfort, and that by repetition of the said form of pastes for local applications. For quick stronger solution a still further increased toleraction in shrinking nasal intumescence the exance can be established in the same anatomic tract of adrenal glands or ephedrin, and simizone. I have also found that this increase of larly acting synthetics are used. tolerance is progressive to a high degree so that The local application of certain metalic salts a tolerance for very strong solutions of said salts in aqueous solution can be tolerated by the nasal can be developed. membranes only in weak dilution which when I have also found that the three said salts can used singly fails of satisfactory astringent action be placed in the amount of about n 2 grain of on nasal tissues. The use of an electric current each in-the same ounce of water and can be to produce iontophoresis of a metalic salt pro- 40 applied to the untreated said anatomic zone with duces permanent impairment of the nasal .substantially the same tolerance as though one mucosa which injures its function. of the said salts alone were so applied, and that Application of adrenal extracts and ephedrin the same increase in amounts of the three said shrinks tissues quickly but within a very short salts in each successive stronger solution can be time the tissues relax and become as edematous 45 tolerated as well by the patient under treatment as before application, and such use produces a as if it were only one of the said salts, and that known undesirable systemic effect. as high degree of tolerance for the three said Important objects and advantages of my insalts in solution can be developed as easily as vention are the production of a, composition of iS the case With a single one Of the said salts in matter especially combined for intranasal appliq l Strength in 80111171011- cation in the treatment of nasal allergy and as- I also found that the astringence developed in sociated conditions, without the necessity for the swollen nasal tissues from the application of anesthetics or for electric modalities, also withall three of said salts in an aqueous solution is out impairment of the nasal mucosa and without much greater than results from the application systemic reaction. M of any one or two of the said salts in the same amount of diluent. I therefore combine the three said salts in the same diluent, and thereby greatly speed the astringent action on the nasal tissues.

In preparing this composition of matter I prefer to use the ingredients in graduated strengths beginning with the equivalent of about 32 grain of each salt to the ounce of distilled water, and then increase the amount of said salts in each successive strength as can be tolerated by the case under treatment, till in resistant cases more than 30 grains of each ofsaid salts can be used in an ounce of water or other diluent.

I may prefer to make up the preparation in a strong solution, for example a saturated solution of the combined salts in water or other diluent, and then dilute the composition to Weaker proportions to suit the tolerance level of the patient.

Good results may be obtained in treating nasal I allergy by means of less expensive ingredients having the same pharmacologic action, which may consist of crystalline cupric sulphate and crystalline zinc sulphate dissolved in commercial glycerol or in ethylene glycol as a solvent with the aid of heat treatment, These ingredients are used in substantially the same amounts and proportions as the preferred embodiment of my invention.

In order to aid in prolonging the suspension of the silver nitrate in the finished solution I may pass a current of direct (galvanic) electricity through the silver solution by suitable electrodes connected with a galvanic or direct currentgenerator of any of the approved types, activating v the solution by a current from the above named apparatus of not less than 20 milliamps nor more than 30 milliamps for each 16 ounces of the solution for a period of not less than 20 seconds nor more than 30 seconds. This current strength and timing are thought to aid suspension of the metalic salt without altering the silver nitrate molecule in the solution.

Although I have set forth and described herein preferred embodiments of my invention, it is to be definitely understood that I do not desire to limit the application of the invention thereto, and any change or changes may be made in the components and the manner of assembling the same, within the spirit of the invention and the scope of the subjoined claim.

I am aware that prior to my invention metals and metalic salts have been used intranasally by means of electric currents and also with the application of heat, as well as high strengthsolutions requiring preliminary anesthetic, therefore I do not claim such combinations broadly, but

I claim:

.A composition of matter for the treatment of nasal allergy consisting of a solution of cupric sulphate and zinc sulphate in glycerol mixed with a solution of silver nitrate in water, the solution containing substantially equal amounts of the metalic salts and adapted to be used in suitably graduated dilutions for application to the mucous membranes involved in nasal allergy and associated conditions.

EDWARD EVERETT EDMONDSON. 

